4-Piperidinone, 1-(3-methoxy-4-nitrophenyl)-
1-(3-Methoxy-4-nitrophenyl)piperidin-4-one
CAS: 761440-64-6
Molecular Formula: C12H14N2O4
4-Piperidinone, 1-(3-methoxy-4-nitrophenyl)- - Names and Identifiers
4-Piperidinone, 1-(3-methoxy-4-nitrophenyl)- - Physico-chemical Properties
| Molecular Formula | C12H14N2O4 |
| Molar Mass | 250.26 |
| Storage Condition | 2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD09972250 |
4-Piperidinone, 1-(3-methoxy-4-nitrophenyl)- - Introduction
1-(3-Methoxy-4-nitrophenyl)piperidin-4-one is an organic compound with the chemical formula C13H16N2O3. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: 1-(3-Methoxy-4-nitrophenyl)piperidin-4-one is an off-white crystalline powder.
-Solubility: It is soluble in some organic solvents, such as chloroform, methanol and ethanol.
-Melting point: Its melting point is 78-80°C.
Use:
-Pharmaceutical field: 1-(3-Methoxy-4-nitrophenyl)piperidin-4-one can be used as a pharmaceutical intermediate for the synthesis of some biologically active compounds.
-Scientific research: It can also be used as an organic synthesis reagent in the research field.
Method:
The synthesis method of -1-(3-Methoxy-4-nitrophenyl)piperidin-4-one usually includes the following steps:
1. In the presence of sulfuric acid, piperidine is reacted with formaldehyde to obtain 4-hydroxymethylpiperidine.
2. Reaction of 4-hydroxymethylpiperidine with 3-methoxy-4-nitrobenzaldehyde under basic conditions yields 1-(3-methoxy-4-nitrophenyl) piperidine-4-aldehyde.
3. Finally, 1-(3-Methoxy-4-nitrophenyl) piperidine-4-aldehyde is reduced with hydrogen and a catalyst such as platinum to give 1-(3-Methoxy-4-nitrophenyl)piperidin-4-one.
Safety Information:
- 1-(3-Methoxy-4-nitrophenyl)piperidin-4-one is a chemical, and care should be taken to comply with relevant safety practices.
-Wear appropriate protective equipment such as gloves, goggles and protective clothing when using the compound.
-Avoid contact with skin, inhalation or ingestion of the compound.
-If exposed or inhaled, seek medical attention immediately.
Nature:
-Appearance: 1-(3-Methoxy-4-nitrophenyl)piperidin-4-one is an off-white crystalline powder.
-Solubility: It is soluble in some organic solvents, such as chloroform, methanol and ethanol.
-Melting point: Its melting point is 78-80°C.
Use:
-Pharmaceutical field: 1-(3-Methoxy-4-nitrophenyl)piperidin-4-one can be used as a pharmaceutical intermediate for the synthesis of some biologically active compounds.
-Scientific research: It can also be used as an organic synthesis reagent in the research field.
Method:
The synthesis method of -1-(3-Methoxy-4-nitrophenyl)piperidin-4-one usually includes the following steps:
1. In the presence of sulfuric acid, piperidine is reacted with formaldehyde to obtain 4-hydroxymethylpiperidine.
2. Reaction of 4-hydroxymethylpiperidine with 3-methoxy-4-nitrobenzaldehyde under basic conditions yields 1-(3-methoxy-4-nitrophenyl) piperidine-4-aldehyde.
3. Finally, 1-(3-Methoxy-4-nitrophenyl) piperidine-4-aldehyde is reduced with hydrogen and a catalyst such as platinum to give 1-(3-Methoxy-4-nitrophenyl)piperidin-4-one.
Safety Information:
- 1-(3-Methoxy-4-nitrophenyl)piperidin-4-one is a chemical, and care should be taken to comply with relevant safety practices.
-Wear appropriate protective equipment such as gloves, goggles and protective clothing when using the compound.
-Avoid contact with skin, inhalation or ingestion of the compound.
-If exposed or inhaled, seek medical attention immediately.
Last Update：2024-04-09 21:00:56
